ANAHEIM, Calif. — When David Ortiz and Manny Ramirez hit, the Red Sox usually are unstoppable. So it was in this American League Divisional Series.

Both players homered yesterday, going back-to-back off Los Angeles Angels of Anaheim starter Jered Weaver to lead off the fourth.

Incredibly, it was the first time they had hit homers in consecutive at-bats this season. It was the second time they had done so in a postseason game; Ortiz and Ramirez also homered back-to-back in Game Three of the ALDS in 2005.

“Me and David,” said the suddenly loquacious Ramirez, “we’re the best 1-2 punch ever.”

“I’m not good at [ranking them in historical context],” said manager Terry Francona, “but I know we’re thrilled that we run them out there because they’re dangerous.”

“I don’t know how much they feed off one another,” said Mike Lowell, “but they’re both special players. And I think in big games like this, you need your big guys to come through and they do it time and time again. I think those two basically set the tone all three games of the series with their bats.”

The home run by Ortiz was his 10th career postseason homer for the Sox, the most in club history. In his last 23 postseason games, Ortiz has nine homers and 27 RBI.

As for Ramirez, his homer was his 22nd career postseason shot, tying him with Bernie Williams for the most ever. He leads all players with 10 Division Series homers and has hit safely in 22 of his last 23 postseason contests.

It’s worth noting, too, that Ramirez got No. 22 in his 84th postseason game and 314th at-bat while Williams had his 22 in 121 games and 465 at-bats.

When Eric Gagne allowed a ninth-inning run yesterday, it was the first run allowed by the bullpen in the series.

The Sox got 4 1/3 innings of scoreless relief from Javier Lopez, Manny Delcarmen, Hideki Okajima and Jonathan Papelbon in Game Two Friday, and Okajima blanked the Angels in the eighth yesterday after taking over from Curt Schilling.

The Angels finally broke through against Gagne, who yielded a leadoff double to Maicer Izturis before wild-pitching him to third. A sacrifice fly from Howie Kendrick then scored the only Angels run of the afternoon.

Schilling shines in the postseason

Schilling’s victory yesterday improved him to 9-2 in his career in the postseason, a winning percentage of .818 — the best ever for pitchers with at least 10 decisions.

He’s undefeated in his career in the Division Series, going 4-0 with a 0.93 ERA in five starts.

“He used to be able to reach back and sometimes hit 97, 98 mph,” said Francona. “When you’re throwing less than that, your margin for error is less. But he didn’t forget how to pitch. He didn’t forget how to compete. And he didn’t forget how to locate.”

Schilling allowed just one walk — a semi-intentional one to Vladimir Guerrero in the third after he had fallen behind in the count.

“I think I looked up in the fifth or sixth inning,” said GM Theo Epstein, “and he had something like 15 balls — and about nine of those were intentional, where he was trying to waste a pitch 0-and-2. I think he only missed three or times [at that point] unintentionally.”

Around the bases

The Sox are 10-3 all-time in the playoffs against the Angels and have won the last nine times ... Boston’s seven-run eighth tied a club record for most runs in a single postseason inning. The Sox also scored seven runs in the fourth inning of Game One of the 2004 ALDS — also against the Angels…. With the Sox comfortably ahead, Francona put in the reserves. Eric Hinske hit for Ortiz in the ninth and Jacoby Ellsbury pinch-ran for Ramirez in the eighth, then remained in the game in left and got an at-bat in the ninth. Among position players, catcher Kevin Cash and Doug Mirabelli, infielder Alex Cora and outfielder Bobby Kielty didn’t play in the series.

smcadam@projo.com