Boston right fielder J.D. Drew injures his wrist when he fails to handle this hit by Baltimore’s Freddie Bynum in the third inning last night.

AP / Nick Wass

BALTIMORE — Right fielder J.D. Drew was the first casualty last night. Center fielder Coco Crisp was the next.

So Jacoby Ellsbury, sporting a nasty black-and-blue bruise on the inside of the left knee where he was hit with a pitch two nights earlier, had to be summoned from the bench. And soon he was joined in the outfield by Gold Glove first baseman Kevin Youkilis.

Such is life on the Red Sox right now.

And while there is a quick turnaround after last night’s 5-4 loss to the Orioles, interim manager Brad Mills (manager Terry Francona is in Arizona for a family funeral) said the organization would have to check the status of its battered Boston outfielders and see if a fresh face needs to be here for this afternoon’s 3 o’clock start at Camden Yards in the finale of the road trip.

It doesn’t look as if Drew will be available. He suffered a sprained left wrist in an unsuccessful diving attempt to catch a looping fly ball hit by Freddy Bynum in the third.

Crisp was struck down by an excruciating headache and began vomiting, said Mills. He had to come out of the game in the sixth, prompting the use of Youkilis in right field for the first time in his career with Sean Casey taking over at first base.

Drew, who was sporting a removable brace on his left wrist after the game, had x-rays taken. They were negative. He said he is worried because he can’t rotate the wrist, a necessary movement for a hitter, but is encouraged by the fact no broken bones showed up in the x-ray.

“I rolled it pretty good out there,” said Drew. “It was one of those plays where you can’t protect yourself. The ball hit the web of the glove and took the wrist around with it. I felt it as soon as I hit the ground.

“The ball was in the glove but once the wrist bent back I didn’t have any strength in the hand to hold onto the ball. It feels a little unstable rotationally. I’m sure it will be sore (today), but we’ll see how it responds. I had never made a dive and flopped over on the wrist. A lot of times when you see a guy do that he breaks his wrist. There are a lot of little bones in there,” said Drew, adding that if it doesn’t get better after a while, he’d probably have an MRI to more clearly assess the damage.

Crisp, meanwhile, was just plain out of it, lying down on a couch in the middle of the clubhouse, his hand shielding his face from the light.

“I don’t know if I can say it’s a migraine, but it was impossible for him to go out there,” said Mills. “He really started vomiting when he came back to the clubhouse.”

skrasner@projo.com