Bills quarterback Trent Edwards, above, could be in for a long day Sunday if All-Pro lineman Jason Peters can’t play Sunday.

AP / David Zalubowski

Getting to Bills quarterback Trent Edwards may be a bit easier than usual for the New England Patriots defense on Sunday — Pro Bowl left tackle Jason Peters missed practice yesterday for the second straight day, and may not be able to play against the Patriots.

The extra-large offensive lineman (he’s listed at 6-foot-4, 340 pounds) did not play last week when Buffalo faced Denver and has been bothered by knee soreness for a few weeks.

Bill Belichick spoke highly of Peters when talking about the Bills’ offensive line this week, and given the challenges he poses, not having him on the field may make it easier for the Patriots’ defensive linemen to cause some havoc.

“Peters is probably as athletic as any lineman in the National Football League,” Belichick said. “He has great size and tremendous power. He’s a great football player.”

Peters was selected to his second straight Pro Bowl last week, though he did not play last year due to injury. He is the top player on an offensive line that weighs in as the NFL’s heaviest: Peters, left guard Derrick Dockery, center Duke Preston, right guard Brad Butler and right tackle Langston Walker average 335 pounds, with Walker tipping the scales at 366 pounds.

However, Walker, like Peters, is very athletic despite being such a large player.

But their athleticism doesn’t give them the chance to run all over the field. Belichick explained that Buffalo’s offensive linemen aren’t asked to pull and get out into space too much: “They will screen and pull from time to time, but they like to play in their area and make you go through them and they are hard to get through,” he said.

Bills’ receiver/punt returner Roscoe Parrish (knee) also did not practice yesterday and missed Wednesday’s session as well; fellow wideout James Hardy (knee) was also reported to have not practiced for the second straight day.

Three key players who did not practice Wednesday were back on the field for Buffalo yesterday, participating on a limited basis: RB Marshawn Lynch (shoulder), LB Kawika Mitchell (knee) and LB Teddy Lehman (groin). Cornerback Jabari Greer (knee) was also limited.

No word on Seymour

The New England players were given yesterday off, so the Pats’ practice report did not offer any update on the status of Richard Seymour. The defensive lineman left last week’s game against Arizona in the first half with a back injury, and did not take part in practice Tuesday or Wednesday.

There were conflicting reports on Seymour’s injury after the game — the Boston Globe called it “minor,” while the Boston Herald said Seymour was in discomfort and may not play against Buffalo. Both papers cited sources.

It is possible that Seymour could be given some time to rest and recuperate but will be on the field on Sunday; last week Matt Light missed the first two days of practice for a shoulder separation suffered in Oakland and returned on Friday, albeit limited. He started against the Cardinals.

Extra points

With 11 receiving yards on Sunday, Randy Moss will move past former Bills great Andre Reed for ninth place on the NFL’s all-time receiving yardage list. Reed finished his career with 13,198 yards; Moss currently has 13,188. Moss is also eight catches shy of passing former Broncos standout Rod Smith for 14th place on the career receptions list; Smith had 849 grabs, while Moss has 842. … With just under 100 yards from scrimmage against the Bills, 10th-year veteran Kevin Faulk has a chance to set a new career best in that category. Faulk has 507 rushing and 478 receiving yards this season, a total of 985; in 2003, he totaled 1,078 yards (638 rushing, 440 receiving). Faulk already has a career-best six touchdowns this year. … With 25 yards rushing, the Patriots will record their best rushing season since 1983, when they gained 2,605 yards on the ground. New England has 2,110 yards heading into the game. … Wes Welker needs four catches to break the single-season franchise record of 112 catches that he set last year. He set a league record by catching at least six passes in each of the first 11 games this year, a streak that ended when he was knocked out of the Pittsburgh game in the third quarter.

smanza@projo.com